Carolina Cannabinoids LLC
Charlotte, NC 28206

Palmitoylethanolamide (PEA)

Our PEA formulations use cold water dispersion technology to enhance PEA bio availability. Our proprietary cold water dispersion technology allows lipophilic active ingredients such as PEA with otherwise relatively low bio availability and poor solubility in water, to be easily dispersed in aqueous environments such as in the stomach, thereby increasing PEA bio availability.

We recommend all our patrons to consult with their physicians before starting with PEA consumption. 

Worldwide, more than 800,000 patients have been treated with PEA, most of them in Italy and Spain, with some in The Netherlands, Germany, UK, Canada and the US, and no serious side effects have been reported.

The Patient’s Guide to PEA

The following contents in this section is reproduced from Scientific Publications referenced bellow for the benefit of patients, prospective patients, healthcare providers, consumers, and anyone interested in learning more about PEA

Palmitoylethanolamide (PEA) has emerged as a potential nutraceutical, known already for more than 50 years. PEA was identified in the 1950s as a therapeutic principle with potent anti-inflammatory properties. Since 1975, its analgesic properties have been noted and explored in a variety of chronic pain states.

The discovery of the cannabis receptors and the nuclear peroxisome proliferator-activated receptors was the beginning of a completely new understanding of many important homeostatic physiologic mechanisms in the human body. These discoveries were necessary for us to understand the analgesic and anti-inflammatory activity of PEA, which is a fatty amide naturally produced within the body as a direct response and repair mechanism to inflammation and pain.

PEA works within the Endocannabinoid System or ECS. ECS helps to maintain balance within our bodies and helps with regulating sleep, immune-system responses, relaxation, pain and more. Our ECS naturally produces cannabinoids called endocannabinoids. PEA much like CBD appears to inhibit the enzyme Fatty Acid Amide Hydrolase (FAAH), which breaks down Anandamide (AEA), an endocannabinoid associated with regulating pain.

What makes PEA unique is its structural similarities to Anandamide (AEA). With PEA, studies have shown it may co-enhance the effects of AEA as well as inhibit FAAH. PEA also counteracts endotoxin-induced inflammation in cells in the same cell lineage as CBD. PEA and CBD share a number of centrally mediated effects which include neuroprotection and attenuation of seizure activity. PEA is a natural food component which can be isolated from soybeans, peanuts and egg yolks. There are no known adverse effects of PEA supplementation.

Indicated Uses

As mentioned in the referenced scientific publications, PEA can be used for Chronic Pain, Neuropathic Pain and Inflammatory conditions such as Rheumatic Arthritis. It is an excellent substitute for CBD for those who are concerned about THC drug tests or it can be taken in conjunction with CBD.